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Abnormal ratio of membrane immunoglobulin classes in mice with an X-linked B-lymphocyte defect

, : Abnormal ratio of membrane immunoglobulin classes in mice with an X-linked B-lymphocyte defect. Journal of Experimental Medicine 142(5): 1316-1321

CBA/N mice have an X-linked genetic defect in B-lymphocyte function manifested by inability to make antibody responses to T-independent antigens. Plasma membrane immunoglobulin (Ig) on spleen, lymph node, and Peyer's patch cells was analysed by lactoperoxidase-catalysed iodination, NP-40 extraction, specific immunoprecipitation, and sodium dodecyl sulphate-polyacrylamide gel electrophoresis.


PMID: 1081577

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