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Abnormal segregation and sex ratio and reduced litter size associated with the siren phenotype in mice

, : Abnormal segregation and sex ratio and reduced litter size associated with the siren phenotype in mice. Teratology 7(2): 195-198

Abnormal segregation ratios in +/srn intercrosses found at term were due to prenatal loss of siren embryos. Litters without sirens were smaller than those with sirens; litters with sirens were smaller than control litters. There was a significant excess of prenatal resorptions in +/srn intercross litters compared with control litters, suggesting reduced reproductive fitness of +/srn females.


PMID: 4725549

DOI: 10.1002/tera.1420070212

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