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Absence of hyponatraemia in African diabetics on chlorpropamide

, : Absence of hyponatraemia in African diabetics on chlorpropamide. Clinica Chimica Acta 43(1): 27-30

The recently reported syndrome of inappropriate antidiuretic hormone secretion with hyponatraemia in diabetic patients on chlorpropamide and the widely reported low normal serum Na in Africans has prompted a study of serum electrolytes in a diabetic population in Nigeria. The results revealed no difference in serum electrolytes between diabetic patients and normal persons and no difference between groups treated with insulin and chlorpropamide. It appears that, at least in the African diabetic patient, hyponatraemia from sulphonylurea compounds does not occur readily.


PMID: 4710819

DOI: 10.1016/0009-8981(73)90113-7

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