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Absorption and excretion of 35sulphur by biliary fistulated rats and guinea-pigs following administration of 35S-sporidesmin

, : Absorption and excretion of 35sulphur by biliary fistulated rats and guinea-pigs following administration of 35S-sporidesmin. Life Sciences, II 11(14): 691-689

Absorption and excretion of radioactivity by both animals was similar in magnitude and rate. The enterhepatic circulation of sporidesmin or its metabolites is reported. It is suggested that differences in spp. sensitivity to sporidesmin must be in variations in sensitivity at the enzyme level, leading to differing toxin concs. within susceptible tissues.


PMID: 4656878

DOI: 10.1016/0024-3205(72)90052-5

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