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Absorption and retention of 144Ce and 95Zr-95Nb in newborn, juvenile and adult rats


, : Absorption and retention of 144Ce and 95Zr-95Nb in newborn, juvenile and adult rats. Health Physics 22(4): 373-378

Following a single oral dose of 5 mu Ci 144Ce or 95Zr-95Nb, retention was 10-1000 X higher in suckling pups than in adult rats. A rapid loss of the nuclides from suckling pups 5-8 days after dosage was replaced around weaning age by a slower exponential decrease. Subcutaneous injection of cortisone acetate into the suckling pups resulted in steeper initial nuclide loss and lower retention. The substantial absorption of the nuclides is mainly due to pinocytosis, which is more active in younger animals.

US$19.90

PMID: 5045197

DOI: 10.1097/00004032-197204000-00009


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