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Absorption of antibiotics by the bovine udder

, : Absorption of antibiotics by the bovine udder. Journal of Dairy Science 58(11): 1637-1644

Absorption of 39 antibiotics into blood from nonlactating bovine udder was compared with absorption of [14C]urea as reference (the ratio of half lives are given). The absorption of urea and most of the antibiotics during the 1st 8-12 h after intramammary infusion showed first order kinetics (absorption occurring at a rate exactly proportional to reactant concn. i.e. urea or antibiotic). The absorption of polymyxin B, colistin, neomycin, spiramycin and several tetracyclines was biexponential (possibly due to udder tissue binding which limits absorption). The physicochemical properties of drugs which appeared to govern their absorption from the udder were the degree of lipid-solubility of the nonionized fraction (undissociated drug) and the dissociation constant (pKa). Antibiotic protein binding also influenced absorption. Drugs that are mainly dissociated in milk at pH 6.8 were absorbed at rates related to their degree of lipid-solubility of nonionized fraction. The concn. of the nonionized molecule in milk was the rate-limiting factor with drugs that were highly lipid-soluble. Results from structurally-related antibiotics and from others with diverse structures and physical properties, added considerable confidence to the assumption that antibiotics are absorbed from the udder by nonionic (passive) diffusion. The blood-milk barrier behaves as an inert lipoid membrane to these drugs.


PMID: 1194466

DOI: 10.3168/jds.S0022-0302(75)84762-X

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