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Absorption, distribution and excretion of CTAB, a quaternary ammonium surfactant, in the rat

, : Absorption, distribution and excretion of CTAB, a quaternary ammonium surfactant, in the rat. Food and Cosmetics Toxicology 13(2): 231-237

Surface-active quaternary ammonium compounds have a high antimicrobial activity and are widely used as sanitizing agents for eating and drinking-utensils and in milk- and other food processing plants. The absorption, distribution and excretion of radioactivity in rats given a single sublethal oral dose of the monoquaternary ammonium surfactant, cetyltrimethylammonium bromide (CTAB) were studied. About 80% of the radioactive dose was found in the gastrointestinal tract 8 h after administration, only small amounts in the blood plasma and about 2% was exreted in the bile in the first 12 h after treatment. Results indicate poor intestinal absorption of CTAB. TLC of bile and urine samples indicated that CTAB was partly metabolized. Within 3 days of ingestion 92% of the administered radioactivity had been excreted in the faeces and 1% in the urine.


PMID: 1169198

DOI: 10.1016/s0015-6264(75)80008-3

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