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Absorption, excretion, and metabolism of 1,3-bis(p-chlorobenzylideneamino)guanidine hydrochloride (Robenz robenidine hydrochloride) in the chicken


, : Absorption, excretion, and metabolism of 1,3-bis(p-chlorobenzylideneamino)guanidine hydrochloride (Robenz robenidine hydrochloride) in the chicken. Journal of Agricultural and Food Chemistry 23(4): 724-730

Chickens of 200 to 300 g bodyweight were given single or daily doses for a week of the coccidiostat robenidine hydrochloride, which is not related chemically to coccidiostats in use until now. They excreted 82% of the 14C label from a single dose within 24 h. Robenidine and 9 metabolites were estimated in droppings and in liver, kidney, blood, bile, muscle, skin and fat. A triazole metabolite was found in liver, fat and skin but not in droppings, so it is important to monitor edible tissue. Robenidine hydrochloride was the main residue in tissues, and the metabolites identified were less toxic, so methods detecting only robenidine may be the most suitable for estimating toxic residues.LD50 in mg/kg bodyweight for mice was of robenidine hydrochloride 390, of p-chlorobenzoic acid 1170, of the triazole metabolite under 4000 and of other metabolites under 5000.

US$19.90

PMID: 1141522

DOI: 10.1021/jf60200a049


Other references

Bouma Arnold H.; Rappeport Melvyn L., 1984: Verification of side-scan sonar acoustic imagery by underwater photography. Pages 279-294 1984

Tang, Z-y.; Huang, Z-y., 1981: The discovery of a Gould's petrel (Pterodroma hypoleuca hypoleuca (Salvin)) from Fuding, Fujian Province. Acta Zootaxonomica Sinica, 61: 59

Joo, J.K.; Jeong, J.E.; Kim, S.C.; Kim, C.W.; Ko, G.R.; Lee, K.S., 2016: Comparison of mechanical artificial shrinkage methods in mouse blastocyst vitrification. This study was designed to determine which mechanical artificial shrinkage (AS) method, conducted by puncture, pipetting, or aspiration, was effective in increasing the re-expansion rate of mouse blastocysts. In each group, 30 mouse blastocysts we...

Feigin, R.D.; Haymond, M.W., 1970: Circadian periodicity of blood amino acids in the neonate. Pediatrics 45(5): 782-791

Bennett, D.M.; Parry, D.W., 1981: Electron-probe microanalysis studies of silicon in the epicarp hairs of the caryopses of Hordeum sativum Jess., Avena sativa L., Secale cereale L. and Triticum aestivum L. Si deposits in the epicarp hairs of the caryopses of mature field-grown barley, oats, rye and wheat were investigated using electron-probe microanalysis. In all 4 cereals, Si was most concentrated at the extreme tips of the hairs. In barley it was...

Kovalski, Y.; Cleper, R.; Krause, I.; Dekel, B.; Belenky, A.; Davidovits, M., 2012: Hyponatremic hypertensive syndrome in pediatric patients: is it really so rare?. Hyponatremic hypertensive syndrome (HHS) is characterized by unilateral renal artery stenosis with secondary hypertension and glomerular and tubular dysfunction due to hyperfiltration and activation of the renin angiotensin system (RAS). Case-diag...

Dahlhoff, M.; Fröhlich, T.; Arnold, G.J.; Zouboulis, C.C.; Schneider, M.R., 2015: LC-MS/MS analysis reveals a broad functional spectrum of proteins in the secretome of sebocytes. Experimental Dermatology 25(1): 66-67

Soc Med Chirur Bordeaux, 1968: Meeting of the societe de medecine et de chirurgie de bordeaux society for medicine and surgery of bordeaux france july 3 1968. Presse Medicale 76(39): 1896

Goodman, D.B.P.; Bulley, M.; Hendricks, M.; Senior, M., 1993: Assessment of the Abbot IMx assay system for the measurement of human chorionic gonadotropin levels in the treatment of ectopic pregnancy. The rapid, accurate determination of serum human chorionic gonadotropin (beta-hCG) levels in the 900- to 2000-IU/L range is a critical element in the treatment of patients with suspected ectopic pregnancy. Using the Abbott IMx system (Abbott Labor...

E.K.eir, D.Y.; Koopman, M.M.W.; Buller, H.R., 2003: Safety of D-dimer and pre-test clinical probability for the exclusion of deep vein thrombosis; a meta-analysis of clinical outcome studies. Deep vein thrombosis (DVT) is a common clinical disorder that is associated with high morbidity and mortality if not properly diagnosed and treated. However, only about 25% of the patients with suspected DVT will have the disease confirmed by obje...