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Absorption, metabolism and excretion of 14C-griseofulvin in man

, : Absorption, metabolism and excretion of 14C-griseofulvin in man. Journal of Pharmacology and Experimental Therapeutics 187(2): 415-422

The metabolic pattern was analysed in plasma and urine, with and without hydrolysis with glusulase. Both the total radioactivity and the conc. of griseofulvin in plasma peaked at 4 h after drug administration, at levels of 2.4 and 1 mg/ml for total radioactivity and griseofulvin, respectively. At 4 h after administration, 14C-griseofulvin accounted for 42% of the total radioactivity in plasma; 6-desmethylgriseofulvin accounted for 44% and the other metabolites comprised 14%.


PMID: 4748557

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