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Acceleration of the growth of populations and of the multiplication of tetrathyridia of Mesocestoides corti Hoeppli, 1925 (Cestoda: Cyclophyllidea) by some cytostatic agents

, : Acceleration of the growth of populations and of the multiplication of tetrathyridia of Mesocestoides corti Hoeppli, 1925 (Cestoda: Cyclophyllidea) by some cytostatic agents. Canadian Journal of Zoology 51(1): 83-90

The effect of cytostatic agents, which are antiproliferative and are widely used in the suppression of malignant tumours and leukaemias, on tetrathyridia of Mesocestoides corti implanted intraperitoneally into various strains of mice was studied. A single injection of cyclophosphamide (200 mg/kg bodyweight) one day after infection increased the total biomass of the tetrathyridial populations in mice dissected 50 days later by 50 to 200%. Less pronounced increases in biomass were produced by dactinomycin given at the rate of 0.35 mg/kg body-weight once a week for 4 to 6 weeks. Although biomass increased, the average size of individual tetrathyridia decreased. Lucanthone and quinacrine were found to accelerate the biomass of tetrathyridial populations much less than the cytostatic agents tested.


PMID: 4696082

DOI: 10.1139/z73-013

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