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Accumulation of amino acids by the perfused rat liver in the presence of ethanol

, : Accumulation of amino acids by the perfused rat liver in the presence of ethanol. Biochemical Journal 134(3): 697-705

The rate of gluconeogenesis from alanine in the perfused rat liver is affected by the presence of other metabolizable substances, especially fatty acids, ornithine and ethanol. Gluconeogenesis is accelerated by oleate and by ornithine. When both oleate and ornithine were present the acceleration was greater than expected on the basis of mere additive effects. Much NH3 and some urea were formed from alanine when no ornithine was added.


PMID: 4749270

DOI: 10.1042/bj1340697

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