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Acetoacetic acid and cholesterol in dietary regimens with different amounts of fat

, : Acetoacetic acid and cholesterol in dietary regimens with different amounts of fat. Physiologia Bohemoslovaca 22(2): 185-194

Rats were given for 90 to 110 days diets of equal energy value with fat supplying 11, 22.1 (control), 45.9 or 69.4% of the energy. Initially the acetoacetate content of liver and blood from rats on high-fat diets increased significantly but after about 90 days values were about normal. The decrease apparently resulted from adaptive gluconeogenesis, increased pyruvate and oxaloacetate production from protein by transamination and adaptively-induced accentuation of the citric acid cycle.


PMID: 4272879

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