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Persistent Borna virus infection in adult hamsters

, : Persistent Borna virus infection in adult hamsters. Archiv fur die Gesamte Virusforschung 40(1/2): 52-57

Adult hamsters were inoculated intracerebrally with Borna virus. Neither clinical nor pathological evidence of Borna encephalitis developed in any of the animals for an observation time of up to 309 days after inoculation. Serum from inoculated hamsters did not show complement-fixing activity during this time. The brains, however, after a variably long incubation time, contained complement-fixing Borna antigen and induced Borna encephalitis when injected into the rabbit. A persistent infection state was obtained in adult hamsters inoculated intracerebrally with Borna virus. The persistent form of the Borna infection in the hamsters sheds some new light on certain aspects of Borna disease. In addition, this model may be useful to the study of persistent infections and possibly slow virus diseases.


PMID: 4632560

DOI: 10.1007/bf01242635

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