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Studies on the biosynthesis of rat parathyroid hormone and proparathyroid hormone: adaptation of the parathyroid gland to dietary restriction of calcium

, : Studies on the biosynthesis of rat parathyroid hormone and proparathyroid hormone: adaptation of the parathyroid gland to dietary restriction of calcium. Endocrinology 93(4): 915-924

Proparathyroid hormone (proPTH) and parathyroid hormone (PTH) were separated from rat gland extracts by a combination of methods including chemical fractionation, gel filtration and ion exchange chromatography. The 2 peptides were similar to bovine proPTH and PTH in their immunoreactivity, molecular weight and size and elution position during chromatography. In radioactive isotope incorporation studies, they exhibited a precursor-product relation comparable to that observed for the bovine prohormone and hormone. After 13 days on a diet containing 0.02% Ca, parathyroid gland weight, size and capacity to synthesize general proteins did not change. In such glands the content of immunoreactive PTH and synthetic rate for PTH doubled, but the synthetic rate of proPTH and the half-life of its cellular pool did not change. The indication was that the parathyroid glands adapted to the low-Ca diet by increasing the efficiency of conversion of proPTH to PTH and thus the control of PTH biosynthesis by Ca may occur at the level of intracellular turnover and degradation of the prohormone.


PMID: 4728221

DOI: 10.1210/endo-93-4-915

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