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Studies on the pharmacokinetics of cyclophosphamide in sheep


, : Studies on the pharmacokinetics of cyclophosphamide in sheep. Arzneimittel-Forschung 23(4): 491-500

Isotopes studies in a ewe and a ram showed that cyclophosphamide was absorbed almost completely three hours after oral administration in a gelatin capsule at 30 mg/kg. A maximum serum concentration of 10-13 mu g/ml was reached 1-2 hours after administration, it then fell rapidly; 60-80% of the oral dose was excreted in the urine in 24 hours. There was a second elimination phase with a relatively long half-life.

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PMID: 4740226


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