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Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. I. In vivo and in vitro effects of the amines

, : Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. I. In vivo and in vitro effects of the amines. International Archives of Allergy and Applied Immunology 46(1): 1-13

Infusion of guinea-pig small intestine with a combination of histamine and 5-hydroxytryptamine 5 to 9 days after infection with 2,000 Trichostrongylus colubriformis infective larvae led to expulsion of a significant number of worms. Infusion with either amine alone during this period, or with both amines during the first 7 days, or from days 8 to 12 was ineffective.


PMID: 4814291

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