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Studies on the starve-refeed response in the rat: non-dependence of derepression and dependence of induction on de novo RNA synthesis

, : Studies on the starve-refeed response in the rat: non-dependence of derepression and dependence of induction on de novo RNA synthesis. Nutrition Reports International 10(4): 189-194

Induction of rat liver glucose-6-phosphate dehydrogenase and malic enzymes was increased in male Wistar rats that were starved and then refed on an inducer diet with 65% glucose, 25% vitamin-free casein, 5% maize oil to nearly twice the amount of rats given the diet to appetite. When 0.5 ml 8-azaguanine was given during refeeding enzyme overshoot was prevented but when given during starvation the overshoot during subsequent refeeding was only partly prevented.


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