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Studies on the tolerance of Debenal (sulphapyrimidine) in dogs and rats

, : Studies on the tolerance of Debenal (sulphapyrimidine) in dogs and rats. Veterinary Medical Review (2/3): 144-162

In semi-chronic and chronic toxicity trials of sulphapyrimidine (Debenal) using daily oral doses of 10, 30 and 60 mg/kg body wt in 18 adult mongrel dogs over a 90-day period and daily oral doses of 2.5, 10, 20, 40 and 80 mg/kg body wt in young male rats over a period of 260 days, no signs of lack of tolerance were observed.


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