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Interaction of amphotericin B and 43 deg hyperthermia


, : Interaction of amphotericin B and 43 deg hyperthermia. Cancer Research 37(3): 761-764

At 43 deg C amphotericin B effectively inactivates mammalian cells in vitro even at doses which are used prophylactically, routinely and continuously in some tissue culture labs. The greatly enhanced killing may reflect interactions between the drug and hyperthermia at the level of the cells' plasma membrane.

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Li, Y-qin.; Si, H-zong.; Xiao, Y-liang.; Liu, C-hong.; Xia, C-cai.; Li, K.; Qi, Y-xiu., 2010: Quantitative structure activity relationship models based on heuristic method and gene expression programming for the prediction of the pK(a) values of sulfa drugs. Quantitative structure-property relationships (QSPR) were developed to predict the pK(a) values of sulfa drugs via heuristic method (HM) and gene expression programming (GEP). The descriptors of 31 sulfa drugs were calculated by the software CODES...