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Reversal of advanced atherosclerosis in rhesus monkeys. 1. Light-microscopic studies


, : Reversal of advanced atherosclerosis in rhesus monkeys. 1. Light-microscopic studies. Atherosclerosis 23(2): 155-176

1. Moderate to severe aortic and coronary atherosclerosis was induced by feeding 4 groups of male rhesus monkeys on a high-fat, high-cholesterol diet for 18 months, after which the first group was killed for assessment of the lesions. During a subsequent 18-month regression period, the second group was fed on a low-fat, low-cholesterol diet with N- gamma -phenylpropyl-N-benzyloxy acetamide (W-1372), and the third group on the same diet without W-1372.

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