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Reversal of ineffective erythropoiesis in pernicious anaemia following vitamin B12 therapy

, : Reversal of ineffective erythropoiesis in pernicious anaemia following vitamin B12 therapy. British Journal of Haematology 35(2): 217-224

Ineffective erythropoiesis was quantitated in a series of patients with pernicious anaemia at different times in relation to vitamin B12 therapy by measuring the incorporation of [15N]delta aminolaevulinic acid and [15N]glycine into early labelled bilirubin. Prior to therapy ineffective erythropoiesis was grossly increased but this was reversed within 24 h of giving vitamin B12, suggesting that most of the existing megaloblasts are enabled to mature into circulating red cells.


PMID: 857850

DOI: 10.1111/j.1365-2141.1977.tb00578.x

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Ciganovic, P.; Milosevic, Z.; Kljajic, R.; Herceg, Z.; Horsic, E., 1990: Study on the tolerance of thiophosphate radiation protection agents by pigs. Twelve 5-month-old pigs of 40 kg body weight were given ethiofos or cistafos at 100, 150 or 200 mg/kg body weight i.m. Mild symptoms of toxicity appeared with the 100 mg/kg dosage; these increased in severity with increasing dosage. The maximum to...

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