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Reversible impairment of cerebral DNA synthesis in thiamine deficiency

, : Reversible impairment of cerebral DNA synthesis in thiamine deficiency. Journal of Laboratory and Clinical Medicine 86(1): 77-90

Female Sprague-Dawley rats weighing 60 to 80 g were fed to appetite on thiamin-free diet; littermate controls were pair-fed with the deprived or fed to appetite on the same diet with added thiamin 22 mu g/g. Rats on thiamin-free diet developed neurological signs, culminating in encephalopathy, in the 5th week and these were completely reversed within 6 h by intraperitoneal injection of 500 mu g thiamin.


PMID: 1151145

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