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Autophagy and apoptosis in liver during the prehaemolytic phase of chronic copper poisoning in sheep


, : Autophagy and apoptosis in liver during the prehaemolytic phase of chronic copper poisoning in sheep. Journal of Comparative Pathology 89(4): 515-530

Fine structural changes in the liver during the prehemolytic phase of chronic Cu poisoning in sheep were investigated in biopsy and post-mortem samples obtained from 24 Finn-Dorset .times. Suffolk ewe lambs. From the beginning of the prehemolytic phase, excessive accumulation of Cu was accompanied by sublethal injury to liver parenchymal cells, reflected by changes in the endoplasmic reticulum and an increase in the numbers of autophagic vacuoles. Later in the prehemolytic phase there was a high incidence of cell death and apoptosis.

US$19.90

PMID: 232106

DOI: 10.1016/0021-9975(79)90043-4


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