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The effect of xantinol-nicotinate (XN) on serum lipoproteins and lipid constellation of low density lipoproteins (LDL) in patients with primary type IIa hyperlipoproteinemia (HLP)


, : The effect of xantinol-nicotinate (XN) on serum lipoproteins and lipid constellation of low density lipoproteins (LDL) in patients with primary type IIa hyperlipoproteinemia (HLP). Protides of the biological fluids: 399-402

Xantinol nicotinate (XN), 50 mg/kg bodyweight daily, significantly reduced serum lipids, free cholesterol, ester cholesterol, phospholipids and triglycerides in 40 patients with primary type IIa hyperlipoproteinaemia. The main effect of XN was on lipids of the low-density lipoprotein (LDL) fraction. The lipids of purified LDL of type IIa patients showed a significant increase of ester cholesterol. The altered lipid composition remained unchanged after cholesterol-lowering treatment with XN.

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