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The use of a short and a long acting oxytetracycline for the treatment of Anaplasma marginale in splenectomized calves


, : The use of a short and a long acting oxytetracycline for the treatment of Anaplasma marginale in splenectomized calves. Journal of the South African Veterinary Association 50(2): 83-85

In South Africa, 20 Afrikander/Simmentaler cross cattle, naturally or experimentally infected with Anaplasma marginale (8 and 12 animals, respectively), were splenectomized and subsequently divided into 3 groups for treatment when the packed cell volume was reduced to between 20 and 24%, irrespective of the level of parasitaemia. 6 animals received a single intramuscular injection of 20 mg/kg body-weight long-acting oxytetracycline (LA); 7 animals received 2 treatments of 10 mg/kg short-acting oxytetracycline (SA) at an interval of 24 hours; 7 animals were untreated controls. Both drugs were effective in controlling A. marginale infections. All the animals treated with oxytetracycline LA survived and they showed a longer relapse interval and higher blood levels of oxytetracycline compared with those treated with oxytetracycline SA. A single death occurred in the latter group. 4 deaths occurred in the untreated group, which also had the shortest relapse interval.

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PMID: 551196


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