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A gene of the immunoglobulin H-chain cluster controls the murine antibody response to pneumococcal polysaccharide type 14


, : A gene of the immunoglobulin H-chain cluster controls the murine antibody response to pneumococcal polysaccharide type 14. Scandinavian Journal of Immunology 12(2): 155-158

Mice of various strains were immunized with pneumococcal polysaccharide type 14 (pneumo-14), and their anti-pneumo-14 antibodies were measured by the Farr test. Mice of strains BALB/c, ST/b, NZB and CBA (Ig allotypes a, e or j) had 300-1700 ng of antibody nitrogen per millilitre of serum on day 7. The corresponding values for C57BL/Ka, RF or AKR mice (allotypes b, c or d) were 40-300 ng/ml. Two families of congenic strains were tested, one with the C57BL and the other with the BALB/c background genome. Their response was either high or low depending on the VH genes, and other gene loci had little effect on the concentration of anti-pneumo-14 antibodies.

US$19.90

PMID: 6777868

DOI: 10.1111/j.1365-3083.1980.tb00052.x


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