+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A genetic defect of granulocyte oxidative metabolism in a man with disseminated aspergillosis

, : A genetic defect of granulocyte oxidative metabolism in a man with disseminated aspergillosis. Journal of Laboratory and Clinical Medicine 97(5): 730-738

A 26 yr old man presented with progressive pneumonia; Aspergillus was grown from cultures of lung, cutaneous nodules and urine. His PMN [polymorphonuclear leukocytes] had a poor CL [chemiluminescence] response after exposure to phagocytic stimuli (Staphylococcus aureus, latex, aggregated IgG and IgG-coated latex) (P < 0.01 vs. controls) and soluble stimuli (PMA [phorbol myristate acetate], sodium fluoride and Con A [concanavalin A]) (P < 0.05). His PMN failed to reduce NBT [nitro-blue tetrazolium], oxidize 14C-1 glucose (P < 0.001) or iodinate proteins (P < 0.001) normally, compared with controls, and his PMN killed Candida albicans and S. aureus abnormally (P < 0.05). The patient was anergic; his plasma inhibited responsiveness of his lymphocytes to stimulation with Aspergillus and Candida antigens. His lymphocytes failed to produce the lymphokine LMIF [leukocyte migration inhibition factor] normally. The patient's 10 mo. old daughter was demonstrated to have the same defects of PMN metabolism and function. The findings in this patient were similar to those in CGD [chronic granulomatous disease] but transmission of the defect from father to daughter and the presence of lymphocyte abnormalities make this diagnosis unlikely. Inhalation of Aspergillus by patients with defective PMN oxidative metabolism may be associated with development of significant infection.


PMID: 6783713

Other references

Oakley T.W.N., 2007: Terrain induced turbulence; case study of Mount Archer, Queensland, Australia. Abstracts - Geological Society of Australia 88(Pages 27

Bogomolova, F.A.; Rybakova, E.P.; Romanova, L.N., 1958: Clinical-anatomical parallels in rheumatic myocarditis in children. Sovetskaia Meditsina 22(1): 74-77

Perrot-Sinal, T.S., 2009: Do these genes make me look fat?. Endocrinology 150(3): 1075-1077

Kovacs G.; Worgall S.; Mall G.; Rosivall L.; Klaus G.; Mehls O., 1991: Effects of growth hormone rhgh and insulin like growth factor 1 rhigh 1 on kidney growth and kidney function. Pediatric Nephrology 5(5): C43

Gehring, K.; Aaronson, N.K.; Taphoorn, M.J.; Sitskoorn, M.M., 2011: Interventions for cognitive deficits in patients with a brain tumor: an update. Patients with brain tumors may suffer from cognitive deficits caused by the disease and/or its treatment. Here, we review recent efforts in the research on prevention or treatment of cognitive deficits in these patients. We conclude that interest...

Misustova J.; Novak L.; Kautska J., 1975: Radioprotective and toxic effects of a mixture of s 2 aminoethyl iso thiuronium bromide hydro bromide and 5 methoxy tryptamine in mice. Physiologia Bohemoslovaca 24(2): 175-182

Anonymous, 2005: Entecavir (Baraclude) for chronic hepatitis B. A new nucleoside analog for treating chronic hepatitis B infection.

Lipsky, B.A.; Berendt, A.R., 2010: Hyperbaric oxygen therapy for diabetic foot wounds: has hope hurdled hype?. Diabetes Care 33(5): 1143-1145

Jibiki, T.; Shimizu, N.; Terashima, I.; Yuki, N., 1994: Guillain-Barré syndrome associated with anti-GQ1b antibody--nosological relationship between Fisher's syndrome and Guillain-Barré syndrome. A 15-year-old man developed diplopia, ataxic gait and bulbar palsy. Two days after the onset of neurological symptoms, neurological examination revealed external ophthalmoplegia, cerebellar ataxia, and areflexia. Muscle weakness in the areas inner...

Quenum, A.; Camain, R., 1959: Histochemical study of the adrenal cortex of Cricetomys gambianus. Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales 153: 697-701