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A lethal hypervitaminosis A syndrome in young monkeys (Macacus fascicularis) following a single intramuscular dose of a water-miscible preparation containing vitamins A, D2 and E


, : A lethal hypervitaminosis A syndrome in young monkeys (Macacus fascicularis) following a single intramuscular dose of a water-miscible preparation containing vitamins A, D2 and E. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 51(4): 331-341

Young monkeys (Macacas fascicularis) weighing 1 to 1.8 kg were given intramuscular doses of a water-miscible preparation of vitamin A as retinyl acetate 500 000 IU/ml, vitamin E 50 IU/ml and ergocalciferol 50 000 IU/ml. At vitamin A doses equivalent to retinol 200 mg/kg or more, early signs of acute toxicity included yawning, apparent drowsiness, nausea and vomiting, head shaking, neck hyperextension, motor hyperactivity and incoordination.

US$29.90

PMID: 6976950


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