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Measurement of zinc flux through plasma in normal and endotoxin-stressed pigs and the effects of Zn supplementation during stress

, : Measurement of zinc flux through plasma in normal and endotoxin-stressed pigs and the effects of Zn supplementation during stress. British Journal of Nutrition 46(1): 119-130

The rates of transport of Zn through plasma were investigated in normal and endotoxin-stressed pigs. 65Zn added to porcine plasma in vitro rapidly equilibrated with the Zn originally present. 65Zn bound to albumin and injected intravascularly into pigs rapidly equilibrated with 2 kinetically distinguishable pools. The first of these pools was mainly associated with the plasma but was significantly larger than the plasma volume and substantially so in Zn-deficient pigs. The 2nd pool appeared to represent a summation of the rapidly-exchangeable Zn within the extravascular tissues. In non-stressed animals, the flux of Zn from the plasma of Zn-deficient pigs was only 1/2 that in Zn-supplemented animals. Administration of endotoxin reduced the plasma Zn concentration of Zn-supplemented pigs but not of Zn-deficient animals. The fractional turnover rates of Zn were not altered in either of the 2 pools following endotoxin. At 10 h after giving endotoxin neither the Zn content of the 2 pools nor the flux of Zn through them differed significantly between Zn-deficient and control pigs. Intravascular infusion of Zn at a rate which essentially prevented the usual depression in plasma Zn concentration following endotoxin failed to alleviate the effects of endotoxin on Zn-supplemented pigs. The reduction in plasma Zn concentration following endotoxin stress appears to be a normal physiological response which is not indicative of an increased metabolic requirement for Zn.


PMID: 7260027

DOI: 10.1079/bjn19810015

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