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Measurement of zinc flux through plasma in normal and endotoxin-stressed pigs and the effects of Zn supplementation during stress


, : Measurement of zinc flux through plasma in normal and endotoxin-stressed pigs and the effects of Zn supplementation during stress. British Journal of Nutrition 46(1): 119-130

The rates of transport of Zn through plasma were investigated in normal and endotoxin-stressed pigs. 65Zn added to porcine plasma in vitro rapidly equilibrated with the Zn originally present. 65Zn bound to albumin and injected intravascularly into pigs rapidly equilibrated with 2 kinetically distinguishable pools. The first of these pools was mainly associated with the plasma but was significantly larger than the plasma volume and substantially so in Zn-deficient pigs. The 2nd pool appeared to represent a summation of the rapidly-exchangeable Zn within the extravascular tissues. In non-stressed animals, the flux of Zn from the plasma of Zn-deficient pigs was only 1/2 that in Zn-supplemented animals. Administration of endotoxin reduced the plasma Zn concentration of Zn-supplemented pigs but not of Zn-deficient animals. The fractional turnover rates of Zn were not altered in either of the 2 pools following endotoxin. At 10 h after giving endotoxin neither the Zn content of the 2 pools nor the flux of Zn through them differed significantly between Zn-deficient and control pigs. Intravascular infusion of Zn at a rate which essentially prevented the usual depression in plasma Zn concentration following endotoxin failed to alleviate the effects of endotoxin on Zn-supplemented pigs. The reduction in plasma Zn concentration following endotoxin stress appears to be a normal physiological response which is not indicative of an increased metabolic requirement for Zn.

US$19.90

PMID: 7260027

DOI: 10.1079/bjn19810015


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Miko, Ladislav, 1993: Effects of poplar windbreaks on soil arthropod communities in heavy soil agroecosystems of East Slovakia. The influence of the simple, four-row poplar windbreak on the oribatid community of the adjacent agroecosystems was studied during the seasons 1986-1989 in the East-Slovak Lowlands. Species composition, community structure, abundance, group domina...

Basavaraj Hulagur; Gangadharappa, N.R., 1999: Monsoon based cropping system in rainfed areas: a study in Karnataka. A study of monsoon cropping systems in 1993/94 in 25 small and 25 large farms in Nagamangala taluk of Mandya district, Karnataka, India, which represents a typical dry belt, revealed that jowar [sorghum], sesame and avare [Lablab purpureus] were g...

Tereshchenko, S.A.; Potapov, D.A., 2002: Correction of light refraction and reflection in medical transmission optical tomography. The effects of light refraction and reflection on the quality of image reconstruction in medical transmission optical tomography of high-scattering media are considered. It has been first noted that light refraction not only distorts the geometric...

Navashin S.M., 1987: Development of the science of antibiotics in the ussr. Antibiotiki i Meditsinskaya Biotekhnologiya 32(11): 806-810

Sohal, G.S.; Knox, T.S.; Allen, J.C.; Arumugam, T.; Campbell, L.R.; Yamashita, T., 1985: Development of the trochlear nucleus in quail and comparative study of the trochlear nucleus, nerve, and innervation of the superior oblique muscle in quail, chick, and duck. The present study was undertaken to examine the development of the trochlear nucleus in quail and to compare the mature trochlear nucleus, nerve, and their sole target of innervation, the superior oblique muscle, in quail, chick, and duck. Study o...

Watson, M.; Hally, R., J.; Mccue, P., A.; Varga, J.; Jimenez, S., A., 1996: Gastric antral vascular ectasia (watermelon stomach) in patients with systemic sclerosis. This report describes 5 patients with systemic sclerosis (SSc) who developed severe, recurrent upper gastrointestinal (GI) bleeding due to gastric antral vascular ectasia (GAVE). The clinical records, the endoscopic findings, and the histologic ap...

Permin, H.; Aldershvile, J.; Nielsen, J.O., 1982: Hepatitis B virus infection in patients with rheumatic diseases. Patients (239) with different rheumatic diseases were investigated for serological markers of hepatitis B virus (HBV) infection. An increased prevalence of anti-hepatitis B surface antigen antibody (anti-HBs) was found in patients with systemic lu...

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Stone, R., 2004: Archaeology. Putting the stone in Stonehenge. Science 304(5679): 1889-1891

Guiang, R.V.; Leones, G.Iang, M.A., 1954: Treatment of Guillain-Barré syndrome with ACTH; report of a case. Journal of the Philippine Medical Association 30(6): 282-285