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Modified G-6-PD/malaria hypothesis

, : Modified G-6-PD/malaria hypothesis. Lancet 1(8158): 51

The correspondent suggests a modification of the original glucose-6-phosphate dehydrogenase (G-6-PD) deficiency/malaria hypothesis which may explain conflicting epidemiological and clinical data. The mechanism proposed involves the interaction of G-6-PD deficiency, malaria and a concomitant oxidant stress (due to favism, drugs or infection). Individuals with GdB, GdB/GdB are not protected against malaria and are not susceptible to oxidant stress. Individuals with GdB-/GdB-, GdB- are protected against lethal malaria but are also under negative selection from oxidant stress. The female heterozygote GdB/GdB-, who has both normal and deficient alleles, is protected from both negative selection of oxidant stress and malaria. This will create a situation whereby balanced polymorphism could arise.


PMID: 6101400

DOI: 10.1016/S0140-6736(80)90597-8

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