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Characterization of the aortic collagens in guinea pigs with chronic vitamin C deficiency

, : Characterization of the aortic collagens in guinea pigs with chronic vitamin C deficiency. Atherosclerosis 46(3): 369-373

Marginal vitamin C deficiency lasting 19 weeks caused hypercholesterolemia and hypertriglyceridemia in guinea pigs. In the thoracic aorta of deficient animals a moderate decline of type I and an increase of type III collagen was observed. Both types of collagen isolated from deficient aortas proved to be slightly underhydroxylated.


PMID: 6847747

DOI: 10.1016/0021-9150(83)90185-5

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