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Effect of metal chelators on excretion and tissue levels of essential trace elements

, : Effect of metal chelators on excretion and tissue levels of essential trace elements. Environmental Research 35(1): 237-245

The influence of 1, 3 and 6 doses of EDTA, diethylenetriaminepentaacetic acid (DTPA) and triethylenetetramine (TETA) on the urinary excretion of Ca, Cu, Fe and Zn, and on their levels in liver, kidneys, heart and serum in rats was investigated to ascertain their suitability in amelioration of metal intoxication. While excretion of all essential trace metals was enhanced significantly, the tissue and serum levels of some increased or decreased after administration of the chelators. The results suggested depletion of some endogenous trace metals from the body and their intertissue redistribution following treatment with these chelating agents.


PMID: 6436015

DOI: 10.1016/0013-9351(84)90132-4

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