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C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle

, : C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle. Genetics 113(4): 853-867

Certain mutations in the unc-105 II gene of Caenorhabditis elegans have dominant effects on morphology and behaviour; animals become small, severely hypercontracted and paralyzed. These unc-105 mutants revert both spontaneously and with mutagens at high frequencies to a wild type phenotype. Most of the reversion events were intragenic, apparently because the null (loss-of-function) phenotype unc-105 is wild type. One revertant defined an extragenic suppressor locus, sup-20X.


PMID: 3744029

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