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Comparative studies of drug liberation from antimycotic ointments on pig skin and on lipid agar

, : Comparative studies of drug liberation from antimycotic ointments on pig skin and on lipid agar. Mykosen 30(1): 38-43

Purpose of this study was to test the release of two different antimycotics from seven different ointment bases. The bases were industrial preparations or ointment bases according to DAB (Deutsches Arzneibuch). The tests were made on samples of isolated pig skins, as described previously by other authors, an on a newly developed lipid-agar, which contains gelatine, lecithin, synthetic pig lard (Caprylic/Capric/Stearic Triglyceride) and hoof powder. Trichophyton mentagrophytes 100/25 Hoechst was used as test strain. The results show a good correlation between the two test-systems. One of two antimycotic preparations tested showed an optimal drug release, the other one was not satisfactory in this respect. The practical use of these results is discussed.


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