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Dietary sodium restriction, blood pressure and sympathetic activity in spontaneously hypertensive rats

, : Dietary sodium restriction, blood pressure and sympathetic activity in spontaneously hypertensive rats. Journal of Hypertension 5(1): 107-113

Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were given from birth sodium diets ranging from severely deficient (9 mu mol) to a regular intake (Na+ 101 mu mol/g food). Blood pressure and sympathetic activity were assessed at 6 and 16 weeks old. At both ages, SHR on 9 mu mol Na+ failed to develop hypertension. SHR on 17 mu mol Na+ exhibited significant reduction of hypertension; SHR on 26 mu mol showed a small amelioration.


PMID: 2884252

DOI: 10.1097/00004872-198702000-00015

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