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Rapid and sensitive quantitative analysis of the new antimalarial N4 --8-quinolinyl-1,4-pentanediamine in plasma by liquid chromatography and electrochemical detection


, : Rapid and sensitive quantitative analysis of the new antimalarial N4 --8-quinolinyl-1,4-pentanediamine in plasma by liquid chromatography and electrochemical detection. Journal of Chromatography 424(2): 347-356

A rapid, sensitive and simple method was developed for the quantitation of the plasma concentration of N4 -(2,6-dimethoxy-4-methyl-5-((3-trifluoromethyl)phenoxy)-8-quinolinyl)-1,4- pentanediamine, a new antimalarial active against Plasmodium vivax. N4-(5-Hexoxy-6-methoxy-4-methyl-8-quinolinyl)-1,4-pentanediamine diphosphate, a similar 8-aminoquinoline, was used as an internal standard.

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