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Contribution of the CD5+ B cell to D-proximal VH family expression early in ontogeny


, : Contribution of the CD5+ B cell to D-proximal VH family expression early in ontogeny. Journal of Immunology 145(8): 2725-2729

The contribution of CD5+ B cells to the preferential expression of VH 7183 and Q52 observed early in development in mice was determined. CD5+ and CD5- B cells from BALB/c mice were isolated by a fluorescence-activated cell sorter, and the expression of particular VH gene families was determined directly by in situ hybridization. The results indicated that CD5+ B cells obtained from adult and newborn animals express Q52 at a higher concentration than in CD5- B cells.

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PMID: 1698861


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