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Efficacy of a new Hoffmann-La Roche compound (Ro 15-5458) against Schistosoma mansoni (Gezira strain, Sudan) in vervet monkeys (Cercopithecus aethiops)

, : Efficacy of a new Hoffmann-La Roche compound (Ro 15-5458) against Schistosoma mansoni (Gezira strain, Sudan) in vervet monkeys (Cercopithecus aethiops). Tropical Medicine and Parasitology 40(3): 335-336

Some compounds of the class 9-acridanone-hydrazones have recently been developed by Hoffmann-La Roche (Basel, Switzerland) and were shown to have antischistosomal effects. One of these compounds (Ro 15-5458/000) was administered at 2 dose levels (25 mg and 15 mg/kg body-weight) to Schistosoma mansoni (Gezira strain, Sudan) infected vervet monkeys. The faecal egg-output was terminated, worm-burden killed and tissue egg-counts were greatly reduced as compared with the untreated control monkey.


PMID: 2515579

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