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Efficacy of a new Hoffmann-La Roche compound (Ro 15-5458) against Schistosoma mansoni (Gezira strain, Sudan) in vervet monkeys (Cercopithecus aethiops)


, : Efficacy of a new Hoffmann-La Roche compound (Ro 15-5458) against Schistosoma mansoni (Gezira strain, Sudan) in vervet monkeys (Cercopithecus aethiops). Tropical Medicine and Parasitology 40(3): 335-336

Some compounds of the class 9-acridanone-hydrazones have recently been developed by Hoffmann-La Roche (Basel, Switzerland) and were shown to have antischistosomal effects. One of these compounds (Ro 15-5458/000) was administered at 2 dose levels (25 mg and 15 mg/kg body-weight) to Schistosoma mansoni (Gezira strain, Sudan) infected vervet monkeys. The faecal egg-output was terminated, worm-burden killed and tissue egg-counts were greatly reduced as compared with the untreated control monkey.

US$29.90

PMID: 2515579


Other references

Pugh, RNH.; Theakston, RDG.; Reid, HA.; Bhar, IS., 1980: Malumfashi Endemic Diseases Research Project, 13. Epidemiology of human encounters with the spitting cobra, Naja nigricollis, in the Malumfashi area of northern Nigeria. Annals of Tropical Medicine and Parasitology, 745: 523-530

Stevens, R.H., 2000: Public health practice in schools of public health: is there a fit?. Public health practice has been a part of schools of public health for a long time and yet it is still an emerging field of scholarship. Practice faculty often are isolated in their schools and not part of the mainstream. This article explores the...

Friedlander, E.M., 1971: Who is the consumer of health care?. Hospital Progress 52(3): 67-71

Lazzara R., 1986: Depression of left bundle automaticity after coronary artery occlusion and reperfusion. Journal Of The American College Of Cardiologyuppl. A: 85a

Korschilgen, J.P.; Selleger, E.L., 1906: Die altesten Papiermacher und ihre Rohstoffe.. Papier-Fabrikant Berlin, 4 2543-2545

Kolesnik, I.D., 1952: Summer sowings of herbage plants.. This work contains tabulated data on the following: comparison of seed yields of lucerne obtained in 1951 from summer and spring sowings (1950) in the Odessa Province; hay and seed yields from summer sowings of sainfoin in 1951 in the Kiro-vograd...

Peters, H.J.; Köhler, H., 1982: Optimized sample dosing with the atomic absorption spectrophotometer AAS 1 N (VEB Carl Zeiss Jena). Zeitschrift für Medizinische Laboratoriumsdiagnostik 23(4): 254-255

Young C.R.; Mcginnis L.K.; Weber P.K., 1992: Glutamine supports in vitro development of sheep embryos in medium lacking pyruvate lactate and glucose. Biology of Reproduction 46(SUPPL 1): 120

Jori, M.C.; Franceschi, M.; Giusti, M.C.; Canal, N.; Piolti, R.; Frattola, L.; Bassi, S.; Calloni, E.; Mamoli, A.; Camerlingo, M., 1990: Clinical experience with cabergoline, a new ergoline derivative, in the treatment of Parkinson's disease. Advances in Neurology 53: 539-543

Romero, I.C.; Mehaffy, C.; Burchmore, R.J.; Dobos-Elder, K.; Brennan, P.; Walker, J., 2011: Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis. The antigen 85 (Ag85) complex of Mycobacterium tuberculosis represents a promising candidate as a novel drug target and pathogenesis factor. Ag85 comprises three proteins Ag85A, B and C, (encoded by the genes fbpA, B, and C), which participate in...