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The serum rifabutin concentrations in a patient successfully treated for multi-resistant Mycobacterium tuberculosis infection

, : The serum rifabutin concentrations in a patient successfully treated for multi-resistant Mycobacterium tuberculosis infection. Journal of Antimicrobial ChemoTherapy 25(3): 490-491

Rifabutin, a recently introduced spiropiperidyl analogue of rifampicin, was used successfully to treat a longstanding (>14 months) case of pulmonary tuberculosis due to a multi-drug-resistant strain of Mycobacterium tuberculosis. A single daily dose of 450 mg was given and provided plasma drug concentrations in some 15-30-fold excess of the MICs of rifabutin against Myco. tuberculosis and Myco. avium-intracellulare.M.


PMID: 2159958

DOI: 10.1093/jac/25.3.490

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