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Ancylostoma ceylanicum: ATP production and effect of anthelmintics

, : Ancylostoma ceylanicum: ATP production and effect of anthelmintics. Indian Journal of Experimental Biology 28(6): 578-581

Dicarboxylic acids and amino acids were found to support mitochondrial phosphorylation in Ancylostoma ceylanicum. Maximum ATP production was found in succinate-supported phosphorylation under aerobic conditions, but dropped to only 2% under anaerobic conditions. Some anthelmintics, particularly mebendazole, significantly inhibited ATP production. The rate of oxygen uptake by the mitochondria was sensitive to anthelmintics, but the degree of inhibition varied greatly.


PMID: 2401530

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