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Angiotensin-1-converting enzyme activity in Mastomys natalensis during Brugia malayi infection


, : Angiotensin-1-converting enzyme activity in Mastomys natalensis during Brugia malayi infection. Medical Science Research 18(6): 215-216

Six 8-week-old male M. natalensis (GRA Geissen strain) were infected sc with 100 L3 B. malayi larvae and killed at 30 days pi (pre-patent infection), 170-180 days pi (patent) or 10-12 months pi (latent). Angiotensin-1-converting enzyme (ACE) activity was then measured in various organs. In the lungs, ACE activity remained elevated throughout the course of infection, sustaining 32, 36 and 19% increases at pre-patent, patent and latent stages of B. malayi infection, respectively.

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