+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A new instrument for measurement of pKa values and partition coefficients (logP)

, : A new instrument for measurement of pKa values and partition coefficients (logP). Brighton crop protection conference, weeds Proceedings of an international conference, Brighton, UK, 22-25 November 1993 (Vol. 2): 789-794

Values of pKa are of fundamental significance in solution chemistry, while octanol/water partition coeff. (quoted as logP values) are useful indicators of the biological activity and environmental properties of molecules. A powerful new instrument is described which automates pKa and logP measurements. It has been successfully used for compounds with multiple overlapping pKa values and logP values as high as 5 and above, and also for poorly water-soluble compounds.


Other references

Selmi, S.; Rtibi, K.; Grami, D.; Sebai, H.; Marzouki, L., 2017: Protective effects of orange (Citrus sinensis L.) peel aqueous extract and hesperidin on oxidative stress and peptic ulcer induced by alcohol in rat. Massive alcohol drinking can lead to gastric ulcer. In the present study we investigated the gastroprotective effect of Citrus sinensis peel aqueous extract (CSPE) and Hesperidin (H) in ethanol (EtOH) induced oxidative stress and peptic ulcer in r...

Harrison, R.A.; Jacques, M.L.; Minguez, M.L.; Miller, N.G., 1992: Behaviour of ejaculated spermatozoa from bull, boar and ram during thin-layer countercurrent partition in aqueous two-phase systems. Ejaculated spermatozoa from bulls, boars and rams were subjected to thin-layer countercurrent partition in aqueous two-phase systems composed of dextran T500 and polyethylene glycol 6000 (PEG) in sucrose-based Hepes-buffered media. In the basal sy...

Zhang, L.; Shen, H.; Zhao, Z.; Bing, Q.; Hu, J., 2016: Cardiac effects of the c.1583 C→G LMNA mutation in two families with Emery-Dreifuss muscular dystrophy. The present study aimed to examine and analyze cardiac involvement in two Emery‑Dreifuss muscular dystrophy (EDMD) pedigrees caused by the c.1583 C→G mutation of the lamin A/C gene (LMNA). The clinical and genetic characteristics of members of...

Siskind, G., 1967: Level of aspiration task as a selective device for psychiatric aides. Psychological Reports 20(3): 814-814

Fernandes, J.; Tardif, G.; Martel-Pelletier, J.; Lascau-Coman, V.; Dupuis, M.; Moldovan, F.; Sheppard, M.; Krishnan, B.R.; Pelletier, J.P., 1999: In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression. The goal of this study was to determine the efficacy of local IL-1Ra gene therapy by intra-articular plasmid injections on structural changes in the meniscectomy rabbit model of osteoarthritis. A partial meniscectomy of the right knee was performe...

Koenig, J.; Eileen, F.Cobb., 2005: Eileen Fahey Cobb RNP, MSN, BSN, BSS, AHS. Making a difference one life at a time. Beginnings 25(4): 14-15

Shannugadan, S., 1989: Patterns of food production and levels of food consumption in India. Food production and its ultimate consumption in India are examined. The rate of population growth and intra-state variations in food production and consumption patterns are discussed. It is suggested that cereals and pulses are the basic ingredien...

Miwa, T.; Tsukamura, M.; Majima, T.; Ando, Y.; Kotetsu, Y., 1975: The effects of tuberactinomycin-N (TUM-N) for severe pulmonary tuberculosis. Kekkaku 50(8): 229-233

Behnam, Aa, 1977: A glimpse into the agriculture and animal industry of Iran with emphasis on cattle production. CENTO Sem Recent Technol Beef Prod: d, Feed Manage Intensive Semi-Intensive Syst, 35-36

Toman, A.; Schwanstecher, M., 2000: The N-terminus of SURs is not involved in formation of drug receptor sites. Naunyn-Schmiedeberg's Archives of Pharmacology 362(4-5 Supplement): R32