geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Crossreaction between antibodies to oxidised low-density lipoprotein and to cardiolipin in systemic lupus erythematosus


, : Crossreaction between antibodies to oxidised low-density lipoprotein and to cardiolipin in systemic lupus erythematosus. Lancet (North American Edition) 341(8850): 923-925

Serum lipoproteins contain phospholipids and modified low-density lipoprotein (LDL) may thus act as a target for antiphospholipid antibodies. Raised concentrations of IgG antibodies against oxidized LDL were found in 47 of 61 (80%) patients with systemic lupus erythematosus (SLE). 46% of patients also had raised concentrations of IgG anticardiolipin antibodies. Binding of anticardiolipin antibodies to solid-phase cardiolipin was inhibited by oxidized LDL but not by native LDL in 16 of 21 sera from SLE patients. These observations suggest crossreactivity between antiphospholipid antibodies, which are closely associated with thrombosis in SLE, and antibodies to oxidized LDL, thus providing a possible link between thrombotic and atherosclerotic complications in SLE.

US$19.90

PMID: 8096266

DOI: 10.1016/0140-6736(93)91213-6


Other references

Leibbrand, W.; Schumacher, J., 1966: In memoriam Joseph Schumacher. Medizinische Klinik 61(46): 1844-1845

Bentrup, N., 2009: German-Austrian recommendations for HIV postexposure prophylaxis. European Journal of Medical Research 13(12): 539-545

Zelenika, K.N.vak; Malvic, T., 2011: Stochastic simulations of dependent geological variables in sandstone reservoirs of Neogene age; a case study of the Klostar Field, Sava Depression. The research presented herein is the first attempt to perform geostatistical simulations on three geological variables, porosity, thickness, and depth to reservoir, in the Croatian part of the Pannonian Basin. The data were collected from a reserv...

Olin-Lewis, K.; Benton, J.L.; Rutledge, J.C.; Baskin, D.G.; Wight, T.N.; Chait, A., 2002: Apolipoprotein E mediates the retention of high-density lipoproteins by mouse carotid arteries and cultured arterial smooth muscle cell extracellular matrices. Lipoprotein retention in the vascular extracellular matrix (ECM) plays a critical role in atherogenesis. Previous studies demonstrated the presence of apo A-I and E in atherosclerotic lesions, suggesting that HDL may be trapped by the artery wall....

McClellan, W.M.; Plantinga, L.C., 2014: A public health perspective on CKD and obesity. End-stage renal disease (ESRD) is a growing health burden for global populations, which has generated keen interest in interventions to prevent or delay the progression of its antecedent chronic kidney disease (CKD). There are biologically plausib...

Marinelli, W.J.; Gittins, C.M.; Gelb, A.H.; Green, B.D., 2008: Tunable Fabry-Perot etalon-based long-wavelength infrared imaging spectroradiometer. Imaging spectrometry enables passive, stand-off detection and analysis of the chemical composition of gas plumes and surfaces over wide geographic areas. We describe the use of a long-wavelength infrared imaging spectroradiometer, comprised of a l...

Dhanuka, O.P., 2003: Gravity of sugar industry's problems in Bihar. This paper discusses the crisis faced by the sugar industry in Bihar, India. The impact of the crisis on sugar prices, supply and demand are presented. Some possible solutions and recommendations to address the problem are outlined.

Lemoine, G.; Tran Viet, T.u., 1984: The Senning technic in the treatment of transposition of the great vessels. Annales de Pediatrie 31(7): 551-554

Borg J., 1989: The storm petrel hydrobates pelagicus in the maltese islands mediterranean sea a review aves procellariiformes. Naturalista Siciliano 13(1-2): 45-52

Dumon, G.; Dumon, L.Gre, L.Gre, J.; Franchini, G., 1954: Ultrasonics in phtisiology; results after a year of trials. Marseille Medical 91(2): 186-190