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Current trends in animal metabolism: the importance of interorgan relationships and intermediary metabolism in the disposition of xenobiotics

, : Current trends in animal metabolism: the importance of interorgan relationships and intermediary metabolism in the disposition of xenobiotics. Pesticide science and biotechnology Proceedings of the Sixth International Congress of Pesticide Chemistry, held in Ottawa, Canada, 10-15 August 1986: 463-470

Knowledge of intermediary xenobiotic metabolism in animals is important because some intermediary metabolites have more biological activity than both the parent xenobiotic and the end products of metabolism observed in the excreta. Qualitative and/or quantitative differences in intermediary metabolism are often responsible for the varying toxicological responses to a xenobiotic by animals of different species.


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