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Dioxins and vitamin K status of the newborn


, : Dioxins and vitamin K status of the newborn. Journal of Environmental Science & Health Part A Environmental Science & Engineering 29(4): 793-802

The effect of exposure to chlorinated dioxins and dibenzofurans on the vitamin K status of the human newborn was investigated in 32 mother-infant pairs. Pre- and postnatal exposure to these xenobiotics was estimated by the concentrations of these compounds in the fat of the breast-milk three weeks after delivery. Vitamin K-1 and PIVKA-II levels were measured in cord blood and in the infants at eleven weeks. Vitamin K-1 concentrations in cord blood were below the detection limit (40 pg/mL) in all samples measured. PIVKA-II could be detected in nine of the 28 available cord blood samples, but no correlation was found with total dioxin concentrations (expressed in toxic equivalents) in the breast-milk. Neither was there a significant correlation with the separate congeners. From the eleven-week-old infants nine blood samples were available. No significant correlation could be found between total dioxin concentrations and vitamin K-1 or PIVKA-II levels. However, there was a significant inverse correlation (P lt 0.05) between the congeners 1,2,3,7,8-PeCDD and 1,2,3,4,6,7,8-HpCDF, and vitamin K-1 levels. A highly significant inverse correlation (P lt 0.001) was found between the congener 2,3,7,8-tetrachlorodibenzofuran (2,3,7,8-TCDF) and vitamin K-1 levels at this age. These results indicate that dioxins, and especially 2,3,7,8-TCDF, may play a role in vitamin K-1 deficiency in the newborn.

US$19.90

DOI: 10.1080/10934529409376072


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