geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of phenylpropanolamine infusion and withdrawal on body weight and dietary composition in male and female rats


, : Effects of phenylpropanolamine infusion and withdrawal on body weight and dietary composition in male and female rats. Physiology & Behavior 54(3): 523-530

Male and female rats with ad lib access to separate sources of carbohydrate, fat, and protein were implanted with minipumps providing one of three dosages (0.0, 40.0, or 80.0 mg/kg/day) of phenylpropanolamine (PPA) for 2 weeks. Body weight, macronutrient intake, and water consumption were measured daily before, during, and after PPA treatment. Phenylpropanolamine lowered body weight and caloric intake in males and females, and water consumption in females, but did not alter dietary composition in either sex. After PPA termination, caloric intake returned to control levels in both males and females. However, body weight returned to control levels in males only, while PPA-treated females continued to weigh less than controls. Phenylpropanolamine termination was associated with significant increases in water consumption and the percentage of total calories consumed from protein and reductions in the percentage of calories from carbohydrate in males. In contrast, water and macronutrient consumption was similar comparing PPA-treated females to controls after drug termination. These results suggest there are sex differences in the effects of PPA termination on water and macronutrient consumption that result in differential weight gain in males and females.

US$19.90

PMID: 8415947

DOI: 10.1016/0031-9384(93)90246-c


Other references

Zanca, P., 1975: Hyperuricemia in cancer of the larynx. Preliminary report. Serum uric acid values were obtained in 94 patients with cancer, prior to and upon completion of radiation therapy. Hyperuricemia was persistent in all of the patients with carcinoma of the larynx. Explanation for this finding is uncertain. Serum...

Phalen, M.J.M.; U.S.A.my, 1917: U.S. Army Methods of Disposal of Camp Refuse. The destruction of kitchen refuse by burning is the only practical method for a camp of anything but the shortest duration. An incinerator may be built by excavating a quadrangle or oval about 6 feet by 3 feet and preferably about 4 feet deep. Thi...

Liu, H.; Lufei, H.; Shi, W.; Chaudhary, V., 2007: Towards ubiquitous access of computer-assisted surgery systems. Traditional stand-alone computer-assisted surgery (CAS) systems impede the ubiquitous and simultaneous access by multiple users. With advances in computing and networking technologies, ubiquitous access to CAS systems becomes possible and promisin...

Janssen, W.; Miyaishi, S.; Koops, E.; Hildebrand, E.; Püschel, K., 1996: Gunshot fatalities in connection with hunting and hunting rifles--causes, prevention and expert evaluation. Fatalities due to gunshot injury by hunting firearm or during hunting, that had been investigated in the Institute of Legal Medicine of Hamburg University during the last 20 years, were retrospectively analyzed from the view points of epidemiology...

Soraisham, A.Singh.; Lodha, A.Kumar.; Singhal, N.; Aziz, K.; Yang, J.; Lee, S.K.; Shah, P.S.; Lee, S.K.; Shah, P.S.; Kajetanowicz, A.; Synnes, A.; Rouvinez-Bouali, N.; Pied-boeuf, B.; Bertelle, V.; Bulleid, B.; Yee, W.; Shivananda, S.; Lee, K-Soon.; Seshia, M.; Barrington, K.; Lefebvre, F.; McMillan, D.; Andrews, W.; Kovacs, L.; Dow, K.; da Silva, O.; Riley, P.; Shah, P.S.; Peliowski, A.; Aziz, K.; Cieslak, Z.; Kalapesi, Z.; Sankaran, K.; Faucher, D.; Alvaro, R.; Canning, R.; Ojah, C.; Monterros, 2014: Neonatal outcomes following extensive cardiopulmonary resuscitation in the delivery room for infants born at less than 33 weeks gestational age. To examine the neonatal mortality and morbidity of infants born at <33 weeks gestational age (GA) who received extensive delivery room cardiopulmonary resuscitation (DR-CPR) immediately after birth. In this retrospective cohort study, we perfor...

Hagevik, A.; Mcclellan, A.C., 1997: Coordination of locomotor activity in the lamprey spinal cord Mechanisms for long distance coupling. Society for Neuroscience Abstracts 23(1-2): 205

Marchetti G.; Taccardi B., 1975: Effects of creatinol o phosphate on the contractility of the heart in situ of the rabbit. Bollettino Societa Italiana Biologia Sperimentale 51(4): 227-231

Bostwick, D.G.; Bensch, K.G., 1985: Gastrin releasing peptide in human neuroendocrine tumours. Neuroendocrine tumours of the lung and gut are known to possess bombesin-like immunoreactivity. The recent observation that gastrin releasing peptide (GRP), a 27 amino acid peptide isolated from the porcine intestine, may be the mammalian analogue...

Vlasyuk, P.A.; Porutskiy, C.V.; Cherednichenko, S.V., 1957: Non-root side-dressing with thiamine and plant growth during florescence. Top-dressing corn with thiamine during the flowering period (in field experiments with both stable and radioactive preparates) stimulated the vertical growth of the stalks and intensified the growth of the reproductive organs during flowering, yie...

Kränzlin, H.T.; Nap, M.A., 2006: The effect of a phasic oral contraceptive containing Desogestrel on seborrhea and acne. To investigate the effect of an oral contraceptive (Novial) on facial seborrhea and moderate acne. In this nonrandomized, group-comparative trial, women aged between 18 and 30 with seborrhea were enrolled. Women used either a phasic oral contracep...