geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

IgE specific immune responses to an African grass (Kikuyu, Pennisetum clandestinum)


, : IgE specific immune responses to an African grass (Kikuyu, Pennisetum clandestinum). Clinical and Experimental Allergy 23(7): 581-586

Kikuyu grass (Pennisetum clandestinum) is widely used as a grazing pasture in Africa and, although it is extensively cultivated as a lawn for sports fields and domestic gardens, its allergenicity has never been studied in vitro. Using an extract of Kikuyu grass pollen, polyacrylamide gel electrophoresis, Western blotting and a monoclonal anti-human IgE antibody, the specific IgE binding, in the serum of 160 allergic and non-allergic patients in the Cape Town area, to a Kikuyu grass extract was studied. IgE in the sera of 43/104 known grass-allergic individuals bound to Kikuyu grass on the Western blots. In addition, 4/28 'non-allergic' control subjects were found to have Kikuyu grass-specific IgE. Five different profiles of specific IgE reactivity to Kikuyu grass antigens were observed. In 29/43 patients, IgE bound to two dominant 48 and 70 kD allergens in the Kikuyu extract. Although a degree of cross-reactivity with Bermuda grass (Cynodon dactylis) was found in immunoabsorption studies, the 48 and 70 kD allergens appear to be unique to Kikuyu grass. Exposure of heparinized blood from Kikuyu grass-positive patients to the Kikuyu extract stimulated the release of histamine from their basophils in vitro. Kikuyu grass pollen is thus identified as an important aero-allergen in South Africa.

US$19.90

PMID: 7693313

DOI: 10.1111/j.1365-2222.1993.tb00897.x


Other references

Ellertsen, L.K.; Storla, D.G.; Diep, L.M.; Brokstad, K.A.; Wiker, H.G.; Hetland, G., 2009: Allergic sensitisation in tuberculosis patients at the time of diagnosis and following chemotherapy. It is still a matter of debate whether there is an association between infection with Mycobacterium tuberculosis (M. tuberculosis) and allergy. Previously, we have shown higher levels of specific IgE to different inhalant allergens and total IgE i...

Tanglertsampan, C.; Patrakarn, S.; Vassansiri, E., 1997: Double use tests for latex allergy. Contact Dermatitis 36(6): 311-312

Laurent, A.; Chahraoui, K., 2012: L’impact du stress professionnel sur les intervenants SMUR. L objectif est d identifier les situations de stress v cues par les intervenants SMUR et de voir dans quelle mesure elles peuvent avoir un impact sur l puisement professionnel et le niveau de d tresse psychologique. Notre population est constitu e...

Thomas, S.V.; Syam, U.; Devi, J.Sucharitha., 2012: Predictors of seizures during pregnancy in women with epilepsy. We aimed to characterize the seizure pattern during pregnancy in a large cohort of women with epilepsy (WWE) and identify possible predictors of seizure relapse during pregnancy. We recorded the antiepileptic drug (AED) use and seizure frequency f...

Hamburger, J.I.; Kadian, G.; Rossin, H.W., 1968: Delay in control of 131-I-treated thyrotoxicosis is avoidable. Journal of Clinical Endocrinology and Metabolism 28(5): 721-724

Zironi, A.; Carlinfanti, E., 1941: The influence of some factors on the biostatic complex in cultures in fluid media. In fluid media, bacteria multiply only to a limited extent, not because of exhaustion of nutrients or the formation of toxic substances, but on account of an inhibiting effect (biostatic complex). The height of the column of the medium influences...

Picouto, Mía.Dolores.; Villar, F.; Braquehais, Mía.Dolores., 2016: The role of serotonin in adolescent suicide: theoretical, methodological, and clinical concerns. Adolescent suicide is a complex phenomenon that has similarities and differences with adult suicidal behavior. Serotonergic (5-HT) dysfunction has extensively been studied in adults and has been postulated as a biological marker for suicide. We co...

Darmon M.C.; Paulin D.J., 1985: Translational activity of messenger rna coding for cytoskeletal brain proteins in newborn and adult mice a comparative study. Translational activity of mRNA coding for cytoskeletal brain proteins was used to determine the relative abundance of the mRNA in the brains of newborn and adult mice. mRNA was translated in a cell-free system containing rabbit reticulocyte factor...

Warren, J.V.; McDowell, E., 1989: Ephraim McDowell (1771-1830). Journal of Laboratory and Clinical Medicine 113(1): 133-134

Morikawa, M.; Inoue, Y.; Sumi, Y.; Kuroda, Y.; Tanaka, H., 2014: Leukocyte deformability is a novel biomarker to reflect sepsis-induced disseminated intravascular coagulation. Sepsis-induced disseminated intravascular coagulopathy is associated with a high mortality rate. The function and deformability of polymorphonuclear leukocytes change in patients with sepsis. The goal of this study was to characterize the changes...