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Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice

, : Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice. American Journal of Pathology 139(2): 263-273

Borrelia burgdorferi dissemination to select target organs was examined on days 1, 2, 3, 4, 7, 10, 15, 21 and 30 after intradermal inoculation of 4-week-old C3H mice. Infection was determined by culture (blood, spleen, kidney, ear punch), polymerase chain reaction (PCR) for outer surface protein A (Osp A) DNA (ear punch), histology and spirochaete histochemistry (spleen, kidney, skin, heart, joints), and Osp A DNA in situ hybridization (joints, heart).


PMID: 1867318

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