+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Metabolism of fenpyroximate in rats

, : Metabolism of fenpyroximate in rats. Journal of Pesticide Science 18(1): 59-66

Metabolism of fenpyroximate, tert-butyl (E)-alpha-(1,3-dimethyl-5-phenoxypyrazol-4-yl-methyleneaminooxyl)-p-toluate in rats was studied. After a single oral administration of (pyrazole-3-14C), (phenyl-14C(U)) or (benzene ring-14C (U))fenpyroximate, the radiocarbon level in the blood increased to reach the maximum level of 0.18, 0.16 or 0.18 mu-g fenpyroximate eq./ml at 12, 12 or 9 hr, respectively, and then decreased at a half-life, of 11.3, 10.6 or 9 hr, respectively. The radiocarbons in 14C-fenpyroximate were rapidly and almost completely excreted into the urine and feces within 72 hr. The excretion rates of radiocarbon into the urine and feces were 26.2 and 65.5% for (pyrazole-3-14C), 26.1 and 63.9% for (phenyl-14C (U)) and 6.4 and 86.9% for (benzene ring-14C(U))fenpyroximate, respectively. Urinary metabolites identified were 1,3-dimethyl-5-phenoxypyrazole-4-carboxylic acid, 4-cyano-1-methyl-5-phenoxypyrazole-3-carboxylic acid and terephthalic acid. Major metabolites in the feces were (E)-4-((1,3-dimethyl-5-phenoxypyrazol-4-yl)methyleneaminooxymethyl)benzoic acid, (E)-2-(4-((1,3-dimethyl-5-phenoxypyrazol-4-yl)methyleneaminooxymethyl)benzoyloxy)-2-methylpropionic acid, (E)-2-(4-((1,3-dimethyl-5-(4-hydroxy)phenoxypyrazol-4-yl)methylene-aminooxymethyl)benzoyloxy)-2-methylpropionic acid,(E)-2-(4-((1-hydroxymethyl-3-methyl-5-phenoxypyrazol-4-yl) methyleneaminooxymethyl) benzoyloxy)-2-methylpropionic acid and 4-hydroxymethylbenzoic acid. Fenpyroximate seemed to be metabolized via oxidation of the t-butyl group and methyl group at 3-position in the pyrazole ring, p-hydroxylation in the phenoxy moiety, N-demethylation, hydrolysis of the t-butyl ester, cleavage of the oxime ether bond and/or E/Z isomerization.


Other references

Freedman J.; Massey A., 1979: Complement components detected on normal human red blood cells taken into edta and citrate phosphate dextrose. Normal red blood cells (RBC) from fresh EDTA and CPD [citrate-phosphate dextrose] blood and from stored CPD blood were examined for the presence of bound subcomponents of C3 [complement component 3] and C4. By serologic agglutination tests, only C...

Kisselev, O.G., 2001: Rhodopsin controls a conformational switch on transducin gamma-subunit. IOVS 42(4): S307, March 15

Van Baak, M.A.; Mooij, J.M., 1994: Effect of glucose infusion on endurance performance after beta-adrenoceptor blocker administration. To investigate the effect of glucose (Glc) infusion on endurance performance after beta-adrenoceptor blockade, eight healthy male volunteers performed four endurance cycle ergometer tests at 67% of maximal work load after 80 mg of propranolol (Pr)...

Zhang, H.; Wang, K.; Liu, Y.; Chan, D.K-S., 2014: Factors associated with stress of conscience among emergency medical technicians in China. The current study was designed to investigate factors related to stress of conscience among emergency medical technicians in China. One hundred and seventy-five doctors and nurses from emergency departments completed questionnaires measuring demog...

Barta, F., 1985: Aspects of thermal bath, health resorts and recreational facilities. Legislation and regulations concerning special types of tourism facilities and resorts are outlined.

Janecki, A.; Khurana, S.; Montrose, M.; Zimniak, P.; Donowitz, M., 1997: Protein kinase C is involved in translocation of endogenous apical NA/H exchanger in human colonic adenocarcinoma cells Caco-2. FASEB Journal 11(3): A513

Ciapponi, L.; Cenci, G.; Gatti, M., 2006: The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability. The Mre11/Rad50/Nbs (MRN) complex and the two protein kinases ATM and ATR play critical roles in the response to DNA damage and telomere maintenance in mammalian systems. It has been previously shown that mutations in the Drosophila mre11 and rad5...

Umea Med Sallsk, 1967: Meeting of umea medicinska sallskap medical society of umea umea sweden february 18 1966. Nordisk Medicin 77(25): 821

Bezhanova M.P.; Glukhov L.V., 1992: Evaluation of the world situation in regard to the significant types of mineral resources in foreign countries. Razvedka i Okhrana Nedr 1992(6): 18

Kirk, A.P.; Jain, S.; Pocock, S.; Thomas, H.C.; Sherlock, S., 1980: Late results of the Royal Free Hospital prospective controlled trial of prednisolone therapy in hepatitis B surface antigen negative chronic active hepatitis. A long-term follow-up of at least 10 years or until death of 44 patients taking part in a controlled prospective trial of prednisolone therapy in hepatitis B antigen negative chronic active hepatitis (lupoid hepatitis) has been performed at the Ro...