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Modulation by dietary vitamin E and selenium of clotting whole blood thromboxane A2 and aortic prostacyclin synthesis in rats

, : Modulation by dietary vitamin E and selenium of clotting whole blood thromboxane A2 and aortic prostacyclin synthesis in rats. Journal of nutritional biochemistry 4(6): 322-326

The effect of dietary vitamin E and selenium (Se) on aortic prostacyclin (PGI2) and cloning whole blood thromboxane (TX) A2 synthesis in 1-month-old Fischer 344 rats was investigated. Rats were fed basal semi-purified diets deficient in vitamin E and Se or basal diet supplemented with either 200 IU vitamin E and/or 0.2 ppm Se per kg diet for 2 months. Ex vivo production of TXB2 and 6-keto-PGF1-alpha, the corresponding stable metabolites of TXA, and PGI2, were measured in whole blood and aortic rings, respectively. Animals fed vitamin E-deficient diet had significantly (P < 0.05) lower plasma levels of alpha-tocopherol than those fed vitamin E-supplemented diet. Plasma Se was undetected and activity of plasma glutathione peroxidase was diminished in rats fed Se-deficient diets. Vitamin E and Se treatments affected TXA2 and PGI2 production differently. Aortic PGI2 synthesis was affected by both dietary vitamin E and Se, whereas whole blood TXA2 synthesis was only affected by dietary vitamin E. These results suggest that vitamin E and Se have specific and different effects on TXA, and PGI2 synthesis, and that their combined supplementation may have a favorable effect on PGI2:TXA2 ratio.


DOI: 10.1016/0955-2863(93)90076-9

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Shee, J.C., 1942: A Clinical Sign in Sandfly Fever. Indian Medical Gazette 77(12): 732-732

Sulochana, C.B., 1961: Soil mycoflora in relation to soil amendments. Addition of lime, organic manure, urea and other amendments to soil results in a shift in microbial balance which may check development of a particular fungal disease. This paper reviews current practices and suggests problems for future research.

Mcleod, K.J.; Rubin, C.T., 1999: Brief exposure to low level, high frequency mechanical loading reduces postural instability. Journal of Bone & Mineral Research 14(SUPPL 1): S260, Sept

Hall J.W., 2000: Salinity issues relating to decommissioned open pits in Western Australia. Proceedings of the

Caporale, L.; Palese, A.; Bortoluzzi, G., 2012: The leadership style as a mitigator of the insurgence of mobbing risk. Results from an empirical research on Italian nurses. The influence of the organizational factors in mobbing onset, is supported by several studies. The leadership style is considered as one of its main antecedents. To investigate the relation between the leadership style adopted by the Nurse Coordin...

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Brodsky, G.; LePage, T.; Quiring, J.; Zeller, R., 1970: Self-evaluative responses in adolescent retardates. American Journal of Mental Deficiency 74(6): 792-795

Timkina, M.I., 1965: Interrelationships between various analyzers in Teleostei. Relationships between various analyzers in the brain of fish (cruscian carp and goldfishes) were studied in acute experiments. Upon the action on the system of one analyzer (strychninization of the brain surface, electrical and photic stimulation)...

Jian, X.; Li, N.; Chen, Q.; Hua, Q., 2017: Model-guided identification of novel gene amplification targets for improving succinate production in Escherichia coli NZN111. Reconstruction and application of genome-scale metabolic models (GEMs) have facilitated metabolic engineering by providing a platform on which systematic computational analysis of metabolic networks can be performed. In this study, a GEM of Escher...

Bozian, R.C., 1954: Concepts of geriatric medicine. Medical Times 82(5): 316-322