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Modulation by dietary vitamin E and selenium of clotting whole blood thromboxane A2 and aortic prostacyclin synthesis in rats


, : Modulation by dietary vitamin E and selenium of clotting whole blood thromboxane A2 and aortic prostacyclin synthesis in rats. Journal of nutritional biochemistry 4(6): 322-326

The effect of dietary vitamin E and selenium (Se) on aortic prostacyclin (PGI2) and cloning whole blood thromboxane (TX) A2 synthesis in 1-month-old Fischer 344 rats was investigated. Rats were fed basal semi-purified diets deficient in vitamin E and Se or basal diet supplemented with either 200 IU vitamin E and/or 0.2 ppm Se per kg diet for 2 months. Ex vivo production of TXB2 and 6-keto-PGF1-alpha, the corresponding stable metabolites of TXA, and PGI2, were measured in whole blood and aortic rings, respectively. Animals fed vitamin E-deficient diet had significantly (P < 0.05) lower plasma levels of alpha-tocopherol than those fed vitamin E-supplemented diet. Plasma Se was undetected and activity of plasma glutathione peroxidase was diminished in rats fed Se-deficient diets. Vitamin E and Se treatments affected TXA2 and PGI2 production differently. Aortic PGI2 synthesis was affected by both dietary vitamin E and Se, whereas whole blood TXA2 synthesis was only affected by dietary vitamin E. These results suggest that vitamin E and Se have specific and different effects on TXA, and PGI2 synthesis, and that their combined supplementation may have a favorable effect on PGI2:TXA2 ratio.

US$19.90

DOI: 10.1016/0955-2863(93)90076-9


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